Where Did COVID Virus Originate From?

Instead, the research, revealed on-line by way of First Release within the journal Science, confirmed {that a} pathogen efficiently jumped from a non-human animal host to human, in what is called a zoonotic occasion.

It posits that the SARS-CoV-2 virus jumped from animals to people not less than twice and maybe as many as two dozen occasions.

“It’s vital that we know as much about the origin of Covid-19 as possible because only by understanding how pandemics get started can we hope to prevent them in the future,” mentioned Joel O. Wertheim, Associate Professor within the Division of Infectious Diseases and Global Public Health at UC San Diego School of Medicine.


“I think there’s been consensus that this virus did in fact come from the Huanan Market, but a strong case for multiple introductions hasn’t been made by anyone else yet,” mentioned Wertheim.

According to researchers, two evolutionary branches of the virus have been current early within the pandemic, differentiated solely by two variations in nucleotides — the fundamental constructing blocks of DNA and RNA.

Lineage B, which included samples from individuals who labored at and visited the market, grew to become globally dominant. Lineage A ramification inside China, and included samples from individuals pinpointed solely to the neighborhood of the market.

If the viruses in lineage A advanced from these in lineage B, or vice versa, Wertheim mentioned this may recommend SARS-CoV-2 jumped solely as soon as from animals to people.

But the examine discovered that the earliest SARS-CoV-2 genomes have been inconsistent with a single zoonotic leap into people. Rather, the primary zoonotic transmission seemingly occurred with lineage B viruses in late-November 2019 whereas the introduction of lineage A into people seemingly occurred inside weeks of the primary occasion. Both strains have been current on the market concurrently.

Researchers arrived at this conclusion by deciphering the evolutionary price of viral genomes to infer whether or not or not the 2 lineages diverged from a single frequent ancestor in people.

The information are highly effective proof that the 2 viral lineages advanced individually and that a number of spillover occasions occurred.

The Wuhan market reportedly contained a sturdy stay wild animal enterprise, with snakes, badgers, muskrats, birds and raccoon canines (a canid indigenous to Asia) and different species offered for meals. Wertheim mentioned he believes there have been seemingly many viral introductions. At least two efficiently made the animal-human leap; different viral strains went extinct.

“While I’m hesitant to call it proof, what we presented is the most comprehensive explanation for the SARS-CoV-2 genomic diversity at the outset of the pandemic,” Wertheim mentioned. “There are really no other good explanations for both of these strains being at the market except for multiple jumps into humans.”

Source: IANS

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