Waste Frog Skin Heals Chronic Wounds: Here’s How?

Through NTU’s innovation and enterprise firm, NTUitive, the patented know-how for changing waste bullfrog pores and skin into pores and skin wound therapeutic merchandise has been solely licensed to Cuprina for scale-up and business manufacturing.

If profitable, this new product will complement Cuprina’s flagship product MEDIFLY, a bio-dressing product of dwell, medical-grade Lucilia cuprina maggots, which is utilized in Maggot Debridement Therapy.


Chronic wounds have an effect on 1 in 20 sufferers in Singapore. Coupled with diabetes affecting 1 in 10 sufferers and a quickly growing old inhabitants, the chance of growing a persistent wound is excessive and demand for reasonably priced persistent wound care is anticipated to extend.

As a part of the scale-up, Cuprina has established a Good Manufacturing Practice (GMP) compliant satellite tv for pc lab on the Life Science Incubator in Singapore, to duplicate NTU’s collagen extraction and dressing product improvement.

Founder and Chief Technology Officer of Cuprina Holdings, Mr Carl Baptista, stated: “Our focus is always on promoting and encouraging natural wound healing, intervening only to help the body do what it does organically. With NTU’s patented technology, we can develop a line of natural, amphibian-derived collagen products that are highly compatible with the human body. It is this compatibility that leads to improved healing outcomes over what is currently available.”

Mr Baptista added that current analysis paperwork the complementary results of maggot remedy and collagen have on situations of wound therapeutic. These research deal with bovine collagen, however what intrigued Cuprina about amphibian-derived collagen, was its probably larger biocompatibility with people in comparison with conventional collagen sources, and due to this fact its means to enhance the standard of wound therapeutic.

Sustainable Way to Turn Waste into Treasure

Currently, 20 million tonnes of fishery by-products, equivalent to fins, scales, and skins, are discarded yearly, and the mixed annual consumption of flesh frog and fish is estimated to be round 100 million kilograms.

Using this seafood waste to create worthwhile collagen is a sustainable strategy to up-cycle and cut back waste for Singapore, because the nation is driving in direction of its Zero Waste Masterplan and inspiring a round bioeconomy.

This analysis and commercialization effort will assist Singapore to attain its intention of turning into a sustainable, resource-efficient, and climate-resilient nation, says Associate Professor Dalton Tay from NTU’s School of Materials Science and Engineering, an knowledgeable in animal and plant biomass valorization, who developed the innovation.

“As part of the NTU 2025 Strategic Plan and its Sustainability Manifesto, we are developing innovative ways to turn waste into useful materials to tackle some of humanity’s greatest challenges. NTU’s expertise of transforming waste biomass into valuable feedstocks is now highly sought after by industry looking towards sustainable sources. In our partnership with Cuprina, we are glad to be able to fulfill both the circular bioeconomy aims and the healthcare demands of Singapore with one innovation,” explains Assoc Prof Tay.

By utilizing this collagen-rich marine by-product as a uncooked materials, the group hopes to scale back wastage and the product price of pure collagen at scale, in order to carry an reasonably priced however efficient wound-care resolution to the general public.

Earlier this 12 months, Cuprina’s joint proposal with NTU to develop and fast-track the commercialization of this distinctive collagen product was introduced as one of many successful entries of the Sustainability Open Innovation Challenge organized by Enterprise Singapore.

How the New Collagen Patch Helps Healing

Wounds sometimes undergo three phases of therapeutic – inflammatory, proliferative, and maturation – the method is very advanced and requires particular interventions at every part. Cuprina designs and tailors merchandise for every part to optimize therapeutic.

During the inflammatory part, the physique produces enzymes that stop an infection from coming into the bloodstream. However, the enzymes additionally stop undesirable matter from being pushed out of the physique, thus making it tough for the wound to heal. MEDIFLY works with these enzymes to wash up and disinfect the wound, and put together the location for the following part. This exercise is significant to make sure the consequences of the brand new collagen patch may be totally maximized to provide optimum therapeutic outcomes.

For the second part, the collagen patch goals to supply a scaffold for the white blood cells and therapeutic brokers to coagulate and kind a protecting layer for the therapeutic to start. It will even encourage sooner restoration by holding the therapeutic wound moist.

In the ultimate part, the collagen patch will proceed to encourage sooner restoration by holding the therapeutic wound moist and offering collagen as a “building block” materials for the pores and skin to mature.

Mr David Quek, CEO of Cuprina Holdings stated the partnership with NTU is the proper instance of how cutting-edge medical merchandise may be developed whereas concurrently eradicating waste from the surroundings.

“The purpose driving our business is harnessing the power of nature to fuel sustainable development. Sustainability and development are not mutually exclusive, to us they are highly compatible. Our partnership with Assoc Prof Dalton Tay and his team at NTU provides a unique opportunity to combine sustainable practices in the form of waste valorization with novel wound care product development. Like Cuprina, pushing the boundaries of science is in NTU’s DNA – we could not ask for a better partner,” Mr. Quek added. The two-year analysis and scale-up partnership embrace plans for the conduct of scientific trials in native hospitals to validate its security and efficacy.

Source: Eurekalert

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