(the physiological barrier between the mind and its blood vessels), addressing the resultant mind irritation by means of therapeutics turns into problematic.
To overcome these hurdles, the group has produced a novel therapeutic technique utilizing a focused ‘gene supply’ system for enhancing the numbers of specialised anti-inflammatory immune cells particularly throughout the mind to limit mind irritation and injury.
Novel Treatment for Brain Injury
“Our bodies have their own anti-inflammatory response, regulatory T cells, which have the ability to sense inflammation and produce a cocktail of natural anti-inflammatories. Unfortunately there are very few of these regulatory T cells in the brain (due to a limited supply of the crucial survival molecule interleukin 2, also known as IL2), so they are overwhelmed by the inflammation following an injury. We sought to design a new therapeutic to boost the population of regulatory T cells in the brain (by allowing more IL2 to be made by brain cells), so that they could manage inflammation and reduce the damage caused by traumatic injury,” says Prof. Liston, Babraham Institute.
The novel viral vector expertise effectively crosses the blood-brain barrier to show its therapeutic advantages. The drug’s potential for controlling mind irritation was additionally efficiently confirmed by the research group by means of their experimental mouse fashions of a number of sclerosis and stroke.
“By understanding and manipulating the immune response in the brain, we were able to develop a gene delivery system for IL2 as a potential treatment for neuroinflammation. With tens of millions of people affected every year, and few treatment options, this has real potential to help people in need. We hope that this system will soon enter clinical trials, essential to test whether the treatment also works in patients.” says Prof. Liston.