Rare Cases of COVID Relapse Seen With Pfizer Pill

News Picture: Rare Cases of COVID Relapse Seen With Pfizer Pill

TUESDAY, May 10, 2022

Rare circumstances of COVID sufferers relapsing after taking the antiviral tablet Paxlovid are elevating questions amongst some consultants.

An earlier examine of 1,000 adults confirmed that Paxlovid was extremely efficient at stopping extreme COVID and the US authorities has purchased sufficient of the drug to deal with 20 million folks.

But there have been studies of signs returning in sufferers a number of days after finishing the five-day routine of Paxlovid, prompting some medical doctors to marvel if these sufferers are nonetheless contagious and will take a second spherical of the drug.

But the US Food and Drug Administration final week suggested in opposition to a second spherical, saying there’s little danger of extreme sickness or hospitalization amongst sufferers who relapse after taking Paxlovid.

The Pfizer drug was examined and approved based mostly on its effectiveness in opposition to the Delta variant and could also be much less efficient in opposition to Omicron, famous Dr. Michael Charness, who works for Boston’s VA well being system.

He handled a 71-year-old vaccinated affected person whose signs eased however then returned, together with a surge in virus ranges, 9 days into his bout of COVID-19,

“The ability to clear the virus after it’s suppressed may be different from Omron to Delta, especially for vaccinated people,” Charness advised the Associated Press,

In the unique examine, virus ranges rose after 10 days in 1% to 2% in these taking both the drug or dummy drugs, Pfizer and the FDA have famous, the AP reported. That fee was about the identical amongst folks taking the drug or dummy drugs, “so it is unclear at this point that this is related to drug treatment,” the FDA acknowledged, the AP stated.

Another potential clarification for uncommon circumstances of relapse amongst sufferers taking Paxlovid is that the dose is not sturdy sufficient to completely suppress the virus in all folks, stated Andy Pekosz, a virologist at Johns Hopkins University in Baltimore. That might result in coronavirus mutations which might be immune to the remedy, he stated.

“We should really make sure we’re dosing Paxlovid appropriately because I would hate to lose it right now,” Pekosz advised the AP, “This is one of the essential tools we have to help us turn the corner on the pandemic.”

More data

Visit the Yale School of Medicine for extra on paxlovid,

SOURCE: Associated Press

By Robert Preidt and Robin Foster HealthDay Reporters

Copyright © 2021 HealthDay. All rights reserved.

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