How Epilepsy Brain Can Aid in Novel Treatment

Another significantly frequent downside confronted by epilepsy sufferers, particularly these with mesial temporal lobe epilepsy, or MTLE is

Almost one-third of all sufferers are affected with drug resistance epilepsy, which can require additional surgical procedure.

“Our study is the first to detail the presence of newborn neurons and an immature version of a related cell type, known as astroglia (neuronal support cell), in patients with epilepsy. Our findings furnish surprising new insights into how immature astroglia might contribute to epilepsy—opening an unexplored avenue toward the development of new anti-seizure medications for millions of people,” says Michael Bonaguidi, an assistant professor of stem cell biology and regenerative drugs, gerontology, and biomedical engineering at USC.

“Currently available seizure medications tend to target neurons, so medications that act on immature astroglia could greatly expand the options for our patients. A new class of drugs could combine with current medical and surgical strategies to control seizures without aggressive surgical removal of parts of the brain that can be critically important for learning, memory and emotional regulation,” says Liu, a professor of neurological surgical procedure, neurology, and biomedical engineering, director of the USC Neurorestoration Center, and director of the USC Epilepsy Care Consortium.

Source: Medindia

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