Covaxin’s third dose demonstrates persistence of immunity in opposition to rising COVID variants, Health News, ET HealthWorld


Covaxin's third dose demonstrates persistence of immunity against emerging COVID variants

New Delhi: Hyderabad-based vaccine developer Bharat Biotech on Wednesday introduced the administration of third dose of its COVID-19 vaccine BBV152 often known as Covaxinafter six months of two-dose vaccination, dramatically elevated neutralizing antibody responses in opposition to each homologous and heterologous strains and confirmed elevated reminiscence B cell response.

The research was performed on 184 topics, who had been randomized 1:1 and acquired both a booster dose of BBV152 or a placebo, 6 months after the first collection of two doses.

Covaxin induced sturdy T cell responses and continued until 6 months, even after antibody decline. These T cell responses have been adopted as much as 12 months in vaccinated people, regardless of receipt of the third dose. T cell responses in flip assist to provide B cell reminiscence response, upon antigen re-exposure.

The complete research has demonstrated a number of advantages of Covaxin, corresponding to long-term immune response, cell mediated immunity, security of booster dose, immunogenicity in opposition to spike protein, N protein and neutralizing antibody responses in opposition to alpha, beta, delta, delta plus and omicron variants . The research has been peer-reviewed and printed within the Journal Nature Scientific Reports.

According to the research the immune responses declined at 6 months, however elevated by 40 fold in topics who acquired a booster dose. Immune responses when assessed in opposition to variants of concern and continued as much as 12 months.

No severe adversarial occasions had been noticed, besides ache on the injection web site, itching and redness, no circumstances of myocarditis, pericarditis, blood clots, or thrombocytopenia had been detected.

Dr. Krishna Ella, Chairman and Managing Director, Bharat Biotech, stated, “Our team has now demonstrated that COVAXIN is a multi epitope vaccine with antibodies against spike, RBD and N proteins. Post booster dose, it has proven neutralizing antibody responses against variants of concern and long-term protection through memory T and B cell responses. We have now achieved our goal of developing a safe and efficacious vaccine with long term protection against a spectrum of variants.”





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