According to guide writer Christine Langton, who performed the analysis as a part of her PhD dissertation.
“We’re one of the larger studies to have looked at both of these contraceptive methods at the same time,” says Langton, now a PhD researcher on the National Institute of Environmental Health Sciences. “We feel we’re contributing to the story, and to the literature, though nothing we did was definitive. This is a piece of the puzzle.”
Women who expertise menopause earlier than the age of 45 are outlined as early menopauseand they’re at a better danger for heart problems, osteoporosis, and dementia, amongst different well being situations. oral contraceptives change hormone ranges and stop ovulation; tubal ligation might have an effect on blood provide to the ovaries, and sure strategies of the process might harm the ovary and surrounding neural tissue, as famous by the researchers, together with senior writer Elizabeth Bertone-Johnson, professor of epidemiology and Langton’s mentor.
“Recently, AMH has become an established marker for the timing of menopause and was found to be strongly associated with the risk of early menopause,” the writer stated. “Yet, the association of reproductive and lifestyle factors with AMH levels remains unclear.”
The staff centered on a subset of 1,420 ladies with early menopause within the Nurses’ Health Study potential cohort who had offered blood samples between 1996 and 1999. A historical past of their oral contraceptive use and tubal ligation started in 1989 and was up to date each two years till their blood was collected.
“Women who reported that their [tubal ligation] The procedure included the use of a clip, ring or band had significantly lower AMH levels compared to women who never had a TL procedure,” the researchers write.
Langton provides that the limitation is the comparatively smaller variety of ladies reporting the kind of tubal ligation.
When it got here to oral contraceptives, “we saw a significant inverse association – the longer the use of oral contraceptives, the lower the AMH levels were,” Langton says. “That particular finding was a little surprising to us because it didn’t completely align with what we saw when we looked at oral contraceptives and early menopause in the larger cohort” of greater than 115,000 ladies.
The inverse proportion between oral contraceptive use and AMH ranges remained vital even after adjusting the associated components comparable to BMI, smoking, alcohol, variety of pregnancies, and breastfeeding.
“We think further research is warranted,” Langton says.